Discoveries in Cardiovascular Health and Disease
Western University, Schulich School of Medicine & Dentistry, Medical Sciences Building, 2nd Floor, London, ON, Canada
Oral Presentations in room M282; Poster Presentations in room D2005
July 4 – 6, 2024
Click here for a downloadable meeting program.
Organizers: Tianqing Peng, Zhuxu Zhang and Qingping Feng (Western University)
Organizing Committee Members: Tianqing Peng, Zhuxu Zhang and Qingping Feng (Western University), Ren-Ke Li and Burton Yang (University of Toronto), Dake Qi (University of Manitoba), Guangdong Yang (Laurentian University), Dawei Zhang (University of Alberta), Ying Wang and Hong-Lin Luo (University of British Columbia), Xi-Long Zheng (University of Calgary), Wenbin Liang (University of Ottawa)
Meeting Program
Thursday, July 4, 2024
1:00 – 5:00 PM Conference Registration Opens
Poster Setup (D2005)
Friday, July 5, 2024
8:20 – 8:50 AM Conference Registration and Poster Setup (D2005)
9:00 – 9:10 AM Opening remarks, Tianqing Peng, Zhuxu Zhang and Qingping Feng (M282)
9:10 – 9:15 AM Remarks from Rob Bartha, Vice Dean of Research and Innovation, Schulich School of Medicine and Dentistry, Western University (video messages)
9:15 – 9:20 AM Remarks from President of ACRE, Xuejun Wang, University of South Dakota, USA
SESSION I. Cardiovascular Injury and Protection
Chairs: Wenbin Liang and Dawei Zhang
9:20 – 9:40 AM Cardiac toxicity of Bruton’s tyrosine kinase (BTK) inhibitors. Anargyros Xenocostas. Associate Professor of Medicine, Hematologist, London Health Sciences Centre, Western University, London, ON
9:40 – 10:00 AM The novel role of protease-activated receptor 2 (PAR2) in mediating myocardial ischemia-reperfusion injury. Dake Qi, Associate Professor of Pharmacy, University of Manitoba, Winnipeg, MB
10:00 – 10:20 AM Vascular regenerative cell deficiencies in South Asians with T2D: A story of diversity in Canadian health care. David Hess, Professor of Physiology and Pharmacology, Scientist at Robarts Research Institute, Western University, London, ON
10:20 – 10:40 AM IPSC modeling for cardiovascular disease. Mark Chandy, Assistant Professor, Robarts Research Institute, Western University, London, ON
10:40 – 11:15 AM Refreshment Break and Poster viewing/Judging (D2005)
SESSION II. Molecular Insights in Cardiovascular Disease
Chairs: Dake Qi and Guangdong Yang
11:15 – 11:35 AM Molecular mechanism of maintaining low-density lipoprotein cholesterol homeostasis and its therapeutic implications. Dawei Zhang, Professor of Pediatrics, University of Alberta, Edmonton, AB
11:35 – 11:55 AM Pressure Sensing by L-type Ca2+ Channels and the Setting of Cerebral Arterial Tone. Don Welsh, Professor of Physiology and Pharmacology, Scientist at Robarts Research Institute, Western University, London, ON
11:55 – 12:15 PM Identifying novel mechanosensitive receptors by custom high-throughput mechanical stimulation systems. Jie Xu, Professor, Sun Yat-sen University, Guangzhou, China
12:15 – 12:35 PM Salt-Inducible Kinase 3: A Friend or Foe in Atherosclerotic Disease? Xi-Long Zheng, Professor of Biochemistry and Molecular Biology, Libin Cardiovascular Institute, University of Calgary, Calgary, AB
12:35 – 2:25 PM Lunch and Poster Viewing/Judging (D2005)
SESSION III. ACRE International
Chairs: Tianqing Peng and Wenbin Liang
2:25 – 2:45 PM Cardiac Pathophysiology of Proteasome Activation by PKA. Xuejun Wang, Professor and Director of the MD/PhD Program, University of South Dakota, Vermillion, SD, USA
2:45 – 3:05 PM Discovery of therapeutic targets for cardiovascular diseases. Lily Fuli Xiang, Associate Professor, Sun Yat-sen University, Guangzhou, China
3:05 – 3:25 PM Advancing causal gene discoveries to innovative targets for CVD. Eugene Chen, Professor, Pharmacology, Molecular and Integrative Physiology, and Internal Medicine, University of Michigan, Ann Arbor, MI, USA
3:25 – 4:00 PM Refreshment Break and Poster Viewing / Judging (D2005)
SESSION IV. Keynote Presentation
Chair: Qingping Feng
4:00 – 4:45 PM Keynote Presentation: Form and Function in Vascular Disease. Dr. Geoffrey Pickering, Professor and Neil McKenzie Chair in Cardiac Care, Robarts Research Institute, Western University, London, ON, Canada
4:45 –5:00 PM Conference Photo
6:30 – 9:00 PM Conference Dinner
Saturday, July 6, 2024
SESSION V. Trainee Presentations
Chairs: Burton Yang and Zhuxu Zhang
9:00 – 9:15 AM Diffusional Regulation of Macrophage Efferocytic Receptor Inactivation by Proteolytic Cleavage. Rachel Nicholson, Department Microbiology and Immunology, Western University, London, ON
9:15 – 9:30 AM A Conductive Biomaterial, PAMBG, Reduces Arrhythmia Related Electrical Dysfunction in-vitro. Adrian Dychiao, Toronto General Hospital Research Institute, University of Toronto, Toronto, ON
9:30 – 9:45 AM Role of STIM1 luminal cysteines in SOCE regulation and cardiac arrhythmogenesis during I/R injury. Yanwen Li, Department of Physiology and Pharmacology, Western University, London, ON
9:45 –10:00 AM Shroom3 loss induces heart defects in the mouse embryo. Jennifer L. Carleton, Children’s Health Research Institute, Western University, London, ON
10:10 – 10:15 AM Gene therapy targeting RIPK3 with the N-terminus of M45 prevents cardiac necroptosis and improves myocardial function in mice under stress. Rui Ni, Lawson Health Research Institute, Western University, London, ON
10:15 – 10:45 AM Refreshment Break and Poster Viewing / Judging (D2005)
SESSION VI. Novel Mechanisms and Cardiovascular Translation
Chairs: Xi-Long Zheng and Lily Fuli Xiang
10:45 – 11:05 AM Regulation of cardiac ion channels by Wnt signalling. Wenbin Liang, Associate Professor of Cellular and Molecular Medicine, University of Ottawa Heart Institute, Ottawa, ON
11:05 – 11:25 AM H2S signaling and muscle health. Guangdong Yang (Laurentian University)
11:25 – 11:45 AM The role of mitochondrial DNA variation in cardiovascular disease risk. Christina Castellani, Assistant Professor of Pathology and Laboratory Medicine, Western University, London, ON
11:45 – 12:05 AM Cardiac fibrosis regulated by circular RNA encoded proteins. Burton Yang, Professor of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON
12:05 – 12:15 PM Trainee Awards Presentation, Dawei Zhang, co-Chair of Awards Committee; Professor, University of Alberta (Group Photo of Awardees)
12:15 – 12:20 PM Closing remarks, Tianqing Peng, General Secretary, ACRE Canada; Professor, Western University
12:20 – 1:00 PM Lunch (D2005)
1:00 – 3:00 PM ACRE Canada Member Business Meeting (M282)
Abstract / Poster Numbers:
- Differential Expression of microRNAs in Patients with End Stage Renal Disease Target the Klotho/FGF23 Signaling Axis and May Attenuate Left Ventricular Hypertrophy. Carmine Antonio Alberga, Ludger Hauck, Daniela Grothe, Christopher Chan and Filio Billia. Toronto General Research Institute, University of Toronto, University Health Network, Toronto, Ontario
- Investigating the Effects of Δ8-tetrahydrocannabinol on the Vasculature Using Induced Pluripotent Stem Cell Disease Modeling. Zina Zein Abdin, Kerry-Ann Nakrieko, Michelle Si, Grace Parraga, Geoffrey Pickering, Aleksandra Leligdowicz, Mark Chandy. Robarts Research Institute, Departments of Physiology and Pharmacology, Western University, London, Ontario
- Mitochondrial ROS-induced serpinA3 expression protects cardiomyocytes against doxorubicin-induced injury. Meggie Vo, Xiaoyun Ji, Rui Ni, Tianqing Peng. Department of Pathology and Laboratory Medicine, Western University, London, Ontario
- Role of eNOS in the beneficial effects of maternal exercise on fetal heart development during pregestational diabetes. Ryleigh Van Neck, Xiangru Lu, Qingping Feng. Department of Physiology and Pharmacology, Western University, London, Ontario
- Platelet-derived exosomes in septic conditions induce inflammation in microvascular endothelial cells. ChangSheng Ding, Mehreen Tufail, Sharon Lu, Nica Borradaile, Qingping Feng. Department of Physiology and Pharmacology, Western University, London, Ontario
- Inhibition of histone deacetylases aggravates doxorubicin-induced injury in cardiomyocytes. Chao Wang, Tianqing Peng. Departments of Medicine and Pathology and Laboratory Medicine, Western University London, Ontario
- Diffusional Regulation of Macrophage Efferocytic Receptor Inactivation by Proteolytic Cleavage. Rachel Nicholson and Bryan Heit. Department of Microbiology & Immunology, Western University, London, Ontario
- The role of SARS-CoV-2 Nucleocapsid Protein in Inflammation. Mehreen Tufail, Xiangru Lu, Stephen Barr, Nica Borradaile, Qingping Feng. Department of Physiology and Pharmacology, Western University, London, Ontario
- Circular RNA AEBP2-modified immunosuppressive dendritic cells for preventing alloimmune rejection in heart transplantation. Amal Abu Omar, Serina Chahal, Qingfeng Zhou, Adam Greasley, Tan Ze Wang, Raj Thapa, Xiufen Zheng. Surgery Department, Western University, London, Ontario
- Profiling Bone Marrow Stem Cell Niche Changes in Ageing. Urooj I. Syed, Christopher J. Howlett, Zia A. Khan. Department of Pathology and Laboratory Medicine, Western University, London, Ontario
- Genetically engineered human embryonic kidney cells are excellent vehicle for patch clamp study of human Cx43 gap junction channels. Yi X. Li, Honghong Chen, and Donglin Bai. Department of Physiology and Pharmacology, Western University, London, Ontario
- An acidic pH environment converts necroptosis to apoptosis in cardiac microvascular endothelial cells. Julia Steriopoulos, Haitao Lu, Laura Xu, Patrick McLeod, Xuyan Huang, Jeffery Min, Tianging Peng, Zhu-Xu Zhang. Department of Pathology and Laboratory Medicine, Western University, London, Ontario
- S-Nitrosylation of the mitochondrial calcium uniporter stabilizes the channel and may increase calcium uptake. Zoya Lehman, Peter B Stathopulos. Department of Physiology and Pharmacology, Western University, London, Ontario
- Microvascular endothelial dysfunction in chronic diabetic complications, cross-organ differences, and similarities induced by altered miR-9 expression. Eric Wang, Honglin Wang, Biao Feng, Subrata Chakrabarti. Department of Pathology and Laboratory Medicine, Western University, London, Ontario
- A Conductive Biomaterial, PAMBG, Reduces Arrhythmia Related Electrical Dysfunction in-vitro. Adrian Dychiao, Minyao Wang, Jun Wu, Shu-Hong Li, Dr. Ren-Ke Li. Toronto General Hospital Research Institute, University of Toronto, Toronto, Ontario
- H2S mediates the protective roles of polysulfides against lipopolysaccharide-induced vascular smooth muscle cell dysfunctions. Boluwaji Peter Aromokunola, Guangdong Yang. School of Natural Sciences, Laurentian University, Sudbury, Ontario
- Nuclear and mitochondrial DNA variation drive cardiovascular disease risk. Phyo Wei Win, Maya Lekhi, Julia Nguyen, Yun-Hee Choi, Christina A Castellani. Department of Pathology and Laboratory Medicine, Western University, London, Ontario
- The role of GPR68 in acute myocardial infarction. Dong-mei Zhong, Donghua Li, Zhilei Huang, Jialing Li, Fu-li Xiang, Jie Xu. Institute of Precision Medicine, First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China
- Over Expression of GATA2 in Atherogenic Macrophage Induce Development of Atherosclerosis. Amena Aktar, Minhyuk Mun, Kasia Wodz, Angela Vrieze, Charles Yin, A Dave Nagpal, Bryan Heit. Department of Microbiology and Immunology, Western University, London, Ontario
- Identifying the link between influenza infection and myocardial infarction. Matthew Arbolino, Aleksandra Leligdowicz, Bryan Heit. Department of Microbiology and Immunology, Western University, London, Ontario
- Sulfonylureas Compromise Microvascular Flow in Mouse Skeletal Muscle. Mohammed El-Lakany, Paulina Kowalewska, Christopher Ellis, and Donald Welsh. Robarts Research Institute, Western University, London, Ontario
- The impact of aging on microvascular barrier function in the lungs during mechanical ventilation. Aminmohamed Manji, Sanjay Mehta, Lefeng Wang, Cynthia Pape, Lynda McCaig, Ruud Veldhuizen, Sean Gill. Department of Physiology and Pharmacology, Western University, London, Ontario
- CircHIPK3: An Immediate Responder to Ischemia Reperfusion Injury in HL-1 Cardiomyocytes. Adam Greasley, Xiufen Zheng. Department of Pathology and Laboratory Medicine, Western University, London, Ontario
- Developing a Novel, Clinically Relevant Hypertensive Model of COVID-19 in the Golden Syrian Hamster. Khandaker Atkia Fariha, Xiangru Lu, Amanda Hamilton, Kaitlin Belletti, Stephen Barr, Qingping Feng. Department of Physiology and Pharmacology, Western University, London, Ontario
- Role of STIM1 luminal cysteines in SOCE regulation and cardiac arrhythmogenesis during I/R injury. Yanwen Li, Kaiyuan Wang, Sharon Lu, Peter Basile Stathopulos, Qingping Feng. Department of Physiology and Pharmacology, Western University, London, Ontario
- Shroom3 loss induces heart defects in the mouse embryo. Jennifer L. Carleton, Rami Halabi, Qingping Feng, Thomas A. Drysdale. Western University, Children’s Health Research Institute, Lawson Health Research Institute, London, Ontario
- The role of CD248 in pressure overload heart diseases. Donghua Li, Dong-mei Zhong, Zhilei Huang, Mingyue Wu, Jie Xu, Fu-li Xiang. Institute of Precision Medicine, First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China
- Wnt5a is arrhythmogenic in both rodent hearts and human iPSC-derived cardiomyocytes. Jerry Wang, Aizhu Lu, Mingke Ni, Hongwei Wang, Cagla Cimenci, Erik Suuronen, Hadi Toeg, Marc Ruel, Darryl R. Davis, Kyoung-Han Kim, Peter Liu, Wayne S.R. Chen, Rob S. Beanlands and Wenbin Liang. University of Ottawa Heart Institute, Ottawa, Ontario
- Gene therapy targeting RIPK3 with the N-terminus of M45 prevents cardiac necroptosis and improves myocardial function in mice under stress. Rui Ni, Xiaoyun Ji, Zhuxu Zhang, Guo-Chang Fan, Zhaoliang Su, Tianqing Peng. Department of Pathology and Laboratory Medicine, Western University, London, Ontario
- Pressure regulation of L-type Ca2+ channels and its role in myogenic response. Galina Yu. Mironova, Miguel Martín-Aragón Baudel, Victor A. Flores-Tamez, Suzanne E. Brett, Manuel F. Navedo, and Donald G. Welsh. Department of Physiology and Pharmacology, Western University, London, Ontario
- Functional Coupling of L-type Ca2+ Channels as a Regulator of Cerebral Arterial Myogenic Tone. Ming-Kin Wong, Galina Yu. Mironova, Michelle Sun Mi Kim, Sanjay Karce, Amy Kwon, Suzanne E. Brett, Donald G. Welsh. Robarts Research Institute, Schulich School of Medicine & Dentistry, Western University, London, Ontario
- Over-expression of YME1L reduces diabetic cardiomyopathy by protecting mitochondrial homeostasis. Ting Cao, Weimin Ding, Rui Ni, Dong Zheng, Tianqing Peng, Zhenya Shen. Department of Cardiovascular Surgery of the First Affiliated Hospital & Institute for Cardiovascular Science, Soochow University, Suzhou, China
- Molecular mechanism of maintaining low-density lipoprotein cholesterol homeostasis and its therapeutic implications. Dawei Zhang, Department of Pediatrics, University of Alberta, Edmonton, Alberta, Canada
- H2S Signaling and Muscle Health. Guangdong Yang, School of Natural Sciences, Laurentian University, Sudbury, Ontario, Canada
The ACRE Canada Scientific Meeting Committee gratefully acknowledges the generous support of our event partners:
